Mothers’perceptions and exposure to information associated with the acceptance of children’s tuberculosis prevention therapy in Bali Indonesia

Authors

  • I Made Arta Port Health Office Bali
  • Anak Agung Sagung Sawitri
  • Ni Ketut Sutiari Fakultas Kedokteran Universitas Udayana

DOI:

https://doi.org/10.53638/phpma.2023.v11.i2.p02

Keywords:

Information, mothers’ perception, tuberculosis prevention therapy (TPT), acceptance

Abstract

Background and purpose: Children face risk of tuberculosis (TB) infection within households where an index case is present. TB prevention therapy (TPT) for children is a recommended measures to provide protection against TB. This study aims to investigate the relationship between maternal perceptions and the information exposure received by mothers with the acceptance of TPT for toddlers.

Methods: A cross-sectional study was conducted in Badung District, Bali Province, using the register of tuberculosis patients from 2018-2019 as the sampling frame. A systematic random selection yielded 138 mothers with eligible criteria out of 226 children. Home interviews was conducted with mothers regarding maternal characteristics, knowledge, toddlers’ characteristics, perceptions, information exposure, and acceptance of TPT for their children. The relationship between acceptance of TPT and perceptions, information, and other variables was tested using Chi-square test, followed by multivariable analysis using forward logistic regression.

Results: The majority of mothers were aged 30-39 years (57.8%), had completed high school (43.5%), unemployed (43.5%), resided in the Kuta sub-district (23.9%), and had ≤2 living children (73.2%). About 19.2% of mothers accepted TPT for their children. The acceptance of TPT for children was significantly associated with information sources from health worker (aOR=26.70; 95%CI: 1.25-569.38), the presence of ≥2 family members with TB (aOR=14.29; 95%CI: 1.22-166.68), duration of child care by the index case ≥8 hours/day (aOR=10.04; 95%CI: 2.05-49.26), receiving complete information (aOR=9.01; 95%CI: 1.64-49.64), and perceiving minimal barriers (aOR=4.08: 95%CI: 1.22-13.62).

Conclusion: Adequate information exposure, longer duration of care by TB patients, and low perceived barriers contribute to the acceptance of TPT for children. Education to parent is essential to improve acceptance to TPT.

References

Hay SI, Abajobir AA, Abate KH, Abbafati C, Abbas KM, Abd-Allah F, et al. Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016. The Lancet. 2017; 390(10100): 1260–1344.

World Health Organization. Global tuberculosis report 2018. Geneva: World Health Organization; 2018.

World Health Organization. Global tuberculosis 2018 [Internet]. 2018. Available from: https://www.who.int/teams/global-tuberculosis-programme/data

Thomas TA. Tuberculosis in children. Pediatric Clinics. 2017; 64(4): 893–909.

Zelner JL, Murray MB, Becerra MC, Galea J, Lecca L, Calderon R, et al. Bacillus Calmette-Guerin and isoniazid preventive therapy protect contacts of patients with tuberculosis. American Journal of Respiratory and Critical Care Medicine. 2014; 189(7): 853–859.

Word Health Organization. Tuberculosis in children [Internet]. 2017. Available from: http://www.searo.who.int/tb/topics/tb_children/en/

Colditz GA, Brewer TF, Berkey CS, Burdick E, Fineberg HV, Mosteller F. Efficacy of BCG vaccine in the prevention of tuberculosis: Meta-analysis of the published literature. Jama. 1994; 271(9): 698–702.

Fine PE. Variation in protection by BCG: Implications of and for heterologous immunity. The Lancet. 1995; 346(8986): 1339–1345.

Kateralis AL, Jackson C, Southern J, Gupta RK, Drobniewski F, Lalvani A, et al. Effectiveness of BCG vaccination against Mycobacterium tuberculosis infection in adults: A cross-sectional analysis of a UK-based cohort. The Journal of Infectious Diseases. 2019; 221(1): 146–155.

Qu M, Zhou X, Li H. BCG vaccination strategies against tuberculosis: Updates and perspectives. Human Vaccines & Immunotherapeutics. 2021; 17(12): 5284-5295.

Perez-Velez CM, Marais BJ. Tuberculosis in children. New England Journal of Medicine. 2012; 367(4): 348–361.

Orme IM. Tuberculosis vaccine types and timings. Clinical and Vaccine Immunology. 2015; 22(3): 249–257.

Bali Province Health Office. Data profil kesehatan Provinsi Bali 2018 [Data of health profile in Bali Province]. Denpasar: Bali Province Health Office; 2018.

Bali Province Health Office. Laporan program penanggulangan tuberkulosis [Report of tuberculosis management program]. Denpasar: Bali Province Health Office; 2019.

Badung District Health Office. Laporan program penanggulangan tuberkulosis [Report of tuberculosis management program]. Badung: Badung District Health Office; 2019.

Assebe LF, Reda HL, Wubeneh AD, Lerebo WT, Lambert SM. The effect of isoniazid preventive therapy on incidence of tuberculosis among HIV-infected clients under pre-ART care, Jimma, Ethiopia: A retrospective cohort study. BMC Public Health. 2015; 15(1): 1–9.

Abossie A, Yohanes T. Assessment of isoniazid preventive therapy in the reduction of tuberculosis among ART patients in Arba Minch Hospital, Ethiopia. Therapeutics Clinical Risk Management. 2017; 13: 361–366.

Martinez L, Cords O, Horsburgh CR, Andrews JR, Acuna-Villaorduna C, Desai Ahuja S, et al. The risk of tuberculosis in children after close exposure: A systematic review and individual-participant meta-analysis. The Lancet. 2020; 395(10228): 973–984.

Teklay G, Teklu T, Legesse B, Tedla K, Klinkenberg E. Barriers in the implementation of isoniazid preventive therapy for people living with HIV in Northern Ethiopia: A mixed quantitative and qualitative study. BMC Public Health. 2016; 16(1): 1–9.

Datiko DG, Yassin MA, Theobald SJ, Cuevas LE. A community-based isoniazid preventive therapy for the prevention of childhood tuberculosis in Ethiopia. International Journal of Tuberculosis and Lung Disease. 2017; 21(9): 1002–1007.

Garie KT, Yassin MA, Cuevas LE. Lack of adherence to isoniazid chemoprophylaxis in children in contact with adults with tuberculosis in Southern Ethiopia. PLoS One. 2011; 6(11): 1–4.

Singh AR, Kharate A, Bhat P, Kokane AM, Bali S, Sahu S, et al. Isoniazid preventive therapy among children living with tuberculosis patients: Is it working? A mixed-method study from Bhopal, India. Journal of Tropical Pediatrics. 2017; 63(4): 274–285.

Shivaramakrishna HR, Frederick A, Shazia A, Murali L, Satyanarayana S, Kumar AM, et al. Isoniazid preventive treatment in children in two districts of South India: Does practice follow policy?. The International Journal of Tuberculosis and Lung Disease. 2015; 18(8): 919–924.

Triasih R, Padmawati RS, Duke T, Robertson C, Sawyer SM, Graham SM. A mixed-methods evaluation of adherence to preventive treatment among child tuberculosis contacts in Indonesia. The International Journal of Tuberculosis and Lung Disease. 2016; 20(8): 1078–1083.

Benjumea-Bedoya D, Marín DM, Robledo J, Barrera LF, López L, Del Corral H, et al. Risk of infection and disease progression in children exposed to tuberculosis at home, Colombia. Colombia Medica. 2019; 50(4): 261–274.

Birungi FM, Graham S, Uwimana J, van Wyk B. Assessment of the isoniazid preventive therapy uptake and associated characteristics: A cross-sectional study. Tuberculosis Research and Treatment. 2018; 1–9.

Abraham C, Sheeran P. The health belief model, Cambridge handbook of psychology, health and medicine. 2nd ed. Cambridge: Cambridge University Press; 2014.

Ministry of Health of The Republic of Indonesia. Pengobatan pencegahan tuberkulosis di Indonesia [Treatment prevention of tuberculosis in Indonesia]. Jakarta: Ministry of Health of The Republic of Indonesia; 2020.

Ministry of Health of The Republic of Indonesia. Petunjuk teknis manajemen dan tatalaksana TB anak [Technical guideline of management and treatment of tuberculosis of children]. Jakarta: Directorate General of Disease Prevention and Control; 2016.

Glanz K, Rimer BK, Viswanath K. Health behavior: Theory, research, and practice. 5th ed. San Fransisco: Jossey Bass; 2015.

Skinner D, Hesseling AC, Francis C, Mandalakas AM. It’s hard work, but it’s worth it: The task of keeping children adherent to isoniazid preventive therapy. Public Health Action. 2013; 3(3): 191–198.

Chiang SS, Roche S, Contreras C, Del Castillo H, Canales P, et al. Barriers to the treatment of childhood tuberculous infection and tuberculosis disease: A qualitative study. The International Journal of Tuberculosis and Lung Disease. 2017; 21(2): 154–160.

Rutherford ME, Ruslami R, Anselmo M, Alisjahbana B, Yulianti N, Sampurno H, et al. Management of children exposed to Mycobacterium tuberculosis: A public health evaluation in West Java, Indonesia. Bulletin of the World Health Organization. 2013; 91(12): 932-941.

Assefa D, Klinkenberg E, Yosef G. Cross sectional study evaluating routine contact investigation in Addis Ababa, Ethiopia: A missed opportunity to prevent tuberculosis in children. PLoS One. 2015; 10(6): 1–10.

Lienhardt C, Fielding K, Sillah J, Tunkara A, Donkor S, Manneh K, et al. Risk factors for tuberculosis infection in sub-Saharan Africa: A contact study in The Gambia. American Journal of Respiratory and Critical Care Medicine. 2003; 168(4): 448–455.

Okwara FN, Oyore JP, Were FN, Gwer S. Correlates of isoniazid preventive therapy failure in child household contacts with infectious tuberculosis in high burden settings in Nairobi, Kenya - a cohort study. BMC Infectious Diseases. 2017; 17(1): 1–11.

Burmen B, Mutai K, Malika T. Isoniazid preventative therapy uptake for child household contacts of tuberculosis index cases, Kisumu County, Kenya, 2014-2015. Journal of Public Health in Africa. 2019; 10(1): 24–30.

Ministry of Communication and Information of Republic Indonesia. Hasil survei indikator TIK 2015 rumah tangga dan individu [Result of survey of TIK indicator 2015 household and individu] [Internet]. 2016. Available from: http://www.kominfo.go.id

Oketechno. Riset ungkap ibu-ibu semakin gencar bermain internet [Study report that mothers eagerly use internet] [Internet]. 2018 (cited 2023 Dec 6). Available from: https://techno.okezone.com/read/2018/09/17/56/1951473/riset-ungkap-ibu-ibu-semakin-gencar-bermain-internet

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Published

2023-12-01

How to Cite

I Made Arta, Sawitri, A. A. S. ., & Ni Ketut Sutiari. (2023). Mothers’perceptions and exposure to information associated with the acceptance of children’s tuberculosis prevention therapy in Bali Indonesia. Public Health and Preventive Medicine Archive, 11(2), 132–143. https://doi.org/10.53638/phpma.2023.v11.i2.p02

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